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#28 increased number of cells at the 2-cell stage
The phenotype for a xerC mutant includes an increased number of cells at the 2-cell stage. XerC is involved in chromosome dimer resolution, but a parent describing "chromosome resolution phenotype" may not be okay since the underlying mechanism is unknown. We should probably keep the parent more vague since it's just what we see when we peer into the microscope.
Can we discuss further? I am unclear as to what this term means. Is this related to cell division? Development? What sort of parent do you recommend?
Marcus
This term is meant to describe cells that normally exist as single cells (i.e. bacillus), showing up in a diplo- arrangement. It would be similar to a cell chaining phenotype, although "chains" are considered 3 cells and above. The cause for this phenotype is generally due to mutations in chromosome resolution or septation machinery, but users querying the ontology with this phenotype may not know the mechanism. The "cell arrangement" parent would be my first choice when deciding where to put these, adding a "aberrant cell arrangement phenotype" as the parent for chaining. Like other nodes, we traditionally made this node to house "state" phenotypes, but broadening the scope of this parent to fit these terms would makes sense.
make sense, not makes sense.
I think this is an example of a cell division phenotype that would be annotated with OMP:0005138 ! decreased septation
def: "An altered septation phenotype where formation of new cell septa is decreased relative to a designated control."
The evidence for the phenotype would be the fraction of cells that exist as pairs or chains rather than single cells.
Suvi and Debby discussed this on 4/2/2015 and decided that the existing term will work. (see previous comment)