Using Mac OS 10.4.11, MeV version 4.0.01 -- you cannot either launch a new session with a cluster or even save that cluster. You can store a cluster but even when going to the cluster manager afterward, you cannot save or launch a new session with that cluster. This is a huge problem since it really makes it very difficult to do downstream analyses on e.g. a ANOVA result.
Additionally, many things do not work with Mac OS 10.5.1.