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The project intends to calculate complex/common disease PRS using associated traits.
Variant selection is achieved using p-value cutoffs and also annotation, LD scores. The annotation provides possible functional weights.
As each trait contributes different risks to disease, this risk score provides a trait level weight. In addition, since selected variants can be significantly associated to multiple traits, these weights are then recalibrated, trait combinations are in fact more than additive.

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Project Members:

• jakelin (admin)