I recently installed the latest version of LXLE as a dedicated build server at home. After a while it stopped responding. I rebooted the machine. Nothing in the system and error logs, no driver clues, video adapter failures, etc. A couple of days later the same problem. And then after each reboot this period was getting shorter. I finally found the reason!
~/.cache/lxsession/LXDE/run.log was getting too big and took all disk space. It looks like rebooting did clean up some space. And if there is no diskspace left everything stops working: nginx, ssh, LXDE (UI) - and it all looked like hardware failure. Very frustrating.
What I did to fix this:
run.log -> /dev/null
And now after a couple of weeks of uptime I can confirm that this fixes the problem.
I am having the same issue. This is a fresh install of raspi OS downloaded and imaged by the official installer (2022-03-12). See attached images of the offending process and the head and tail outputs of run.log