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sb_holmbonf flag?

2015-09-16
2015-09-17
  • jessica preston

    jessica preston - 2015-09-16

    Hello, I'm sorry but I can't seem to find this information in the manual. Can you tell me what the flag sb_holmbonf means in the output vcf? I have a lot of SNPs with this flag. Thanks!

    eg

    sb_holmbonf DP=8333;AF=0.009720;SB=179;DP4=4220,3897,78,3

     
    • Andreas Wilm

      Andreas Wilm - 2015-09-17

      Hi Jessica,

      these are SNVs that show significant strand bias (sb) and are therefore
      filtered. Corresponding pvalues were corrected using the Holm Bonferroni
      method (holmbonf). This is the default setting. The vcf header should
      contain one line entry describing this. It's also briefly mentioned in the
      2012 LoFreq paper.

      Andreas
      On 17 Sep 2015 02:37, "jessica preston" jpreston555@users.sf.net wrote:

      Hello, I'm sorry but I can't seem to find this information in the manual.
      Can you tell me what the flag sb_holmbonf means in the output vcf? I have a
      lot of SNPs with this flag. Thanks!

      eg

      sb_holmbonf DP=8333;AF=0.009720;SB=179;DP4=4220,3897,78,3

      sb_holmbonf flag?
      https://sourceforge.net/p/lofreq/discussion/general/thread/15a6c25f/?limit=25#c43e


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