Fedora core 5, Kernel 2.6.15 - Attempting to write a block greater than 4kb causes the OS to hang for a very long time. Eventually the OS will partially recover (mouse pointer will unfreeze, keyboard will work...but iSCSI services will not run and I have been unable to start iSCSI services without rebooting the system).
This is a problem when attempting to write to an iSCSI attached tape drive as the backup software I am using (HP Data Protector Express) writes exclusively in 64kb blocks.
This problem only occurs when writing above 4kb; reading at 64kb works fine.
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What versions of the iscsi initiator are you using? If you are using a FC rpm do "rpm -q iscsi-initiator-utils".
There has been a problem with open-iscsi and tape, because the tape driver assumes the initiator supports clustering and the initiator does not. In the upstream kernel this is fixed though. For FC5, if you update to the current FC kernel (I think it is 2.6.18 or .19 based) this should be fixed.
For linux-iscsi, I am not sure if it supported tape. There had been several bug reports for a similar reason. Do you see a oops trace in /var/log/messages?