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I have experienced problems with USB as well. I use the
usb-storage module to access a portable harddisk (archos
jukebox)

When the preemptible kernel patch is applied, and I begin
transfer of a large file (both reading and writing), the system
locks up hard! This happens at a random point during transfer,
but I haven't managed to transfer more than 300MB before the
system locks up.

I haven't noticed any throughput changes though..

tested on

kernel : 2.4.20 (both +SMP and -SMP)

mobo : VIA 8235 chipset (UDMA 133)

proc : athlon xp 2000