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I ran into a similar issue and the thing that fixed it for me was when I referened the DataMatrix object, I passed in the Encoding Type "ASCII" as a parameter even though I was only passing in clear TEXT. That appeared to fix the problem (I checked the image it produced against this website http://datamatrix.kaywa.com/ and the images are now identical.)

Dim NewDataMatrix As New DataMatrix("ABCDEFGHIJKLMNOPQRSTUVWXYZ1234567890-+!@#$%^&*()", EncodingType.Ascii)

I hope this helps you out.

-IamTheGre