When Xiphos window is focused, and keyboard shortcut is switched to a non-Latin layout (Cyrillic in my case), shortcuts don't work. I use 64-bit build on Debian GNU/Linux. Shortcuts work in other GTK2 and GTK3 apps (though there's a history of a similar bug in GTK projects, see, for instance https://bugs.launchpad.net/unity/+bug/1226962
https://bugs.launchpad.net/ubuntu/+source/libreoffice/+bug/1246583
https://bugzilla.mozilla.org/show_bug.cgi?id=791175
https://bugzilla.mozilla.org/show_bug.cgi?id=69230)
closed here in sourceforge as we complete our move to github.
see https://github.com/crosswire/xiphos/issues.
use the Labels pulldown there to distinguish between bugs and enhancements ("feature requests").