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#68 PTN000186208 mapping to GO:0005663

PAINT
closed-accepted
nobody
None
5
2015-08-19
2015-03-11
Ingrid
No

This term shows up for E. coli HolB and DnaX; I should have thought this would have failed a taxon constraint.

http://www.ebi.ac.uk/QuickGO/GProtein?ac=P28631
http://www.ebi.ac.uk/QuickGO/GProtein?ac=P06710

Thanks,
Ingrid

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PAINT: #68

Discussion

  • Pascale Gaudet

    Pascale Gaudet - 2015-08-19

    Ingrid,

    I am surprised that you think the taxon constraints should have caught this, since the definition of the term clearly states that there are prokaryote equivalents:
    "A complex of five polypeptides in eukaryotes, and two in prokaryotes, that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. Source: PMID:14646196, PMID:16172520, PMID:14614842"

    Right now the taxon rule:
    GOTAX:0000057 GO:0005623 cell only_in_taxon 131567 cellular organisms

    Thanks,
    Pascale

     

  • Pascale Gaudet

    Pascale Gaudet - 2015-08-19
    • status: open --> closed-accepted
     

  • Ingrid

    Ingrid - 2015-08-19

    Hi Pascale,

    Right, I did not read the definition carefully; I was in a hurry, and it just sounded very eukaryotic to me. In my defense, it looks like the "and two in prokaryotes" was added as an afterthought to the definition, with two of the cited papers referring to archaea. As far as bacteria go, I have not heard of a replication factor C complex nor of PCNA, although me not having heard of such things is by no means evidence that they don't exist. If the term really does apply to bacteria, it would be nice to see a more inclusive name/synonyms for the term. Should this be moved to the ontology tracker?

    Thanks,
    Ingrid

     

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