#9894 NTR: CERF complex

MGI
closed-duplicate
5
2013-01-15
2012-12-11
No

HI,

In PMID: 15640247, they report identification of a novel nucleosome remodeling complex from human containing SNF2L and also CECR2, as distinct from the previously identified NURF nucleosome remodeling complex, which in humans also contains SNF2L, but not CECR2.

term name: CERF complex
is_a: GO:0031010 - ISWI complex

Here is a proposal for a def, based loosely on the current def of its sibling term for the related "NURF complex" (though I'll have comments on that too).

Def: An ISWI-type chromatin remodeling complex that facilitates nucleosome mobility in an ATP-dependent manner. In contrast to some other chromatin remodeling complexes, the ATPase activity of NURF requires nucleosomes rather than free DNA or histones. In humans, this complex contains at least SNF2L and CECR2.

Note: The phrase "nucleosome remodeling factor complex" is currently an exact synonym of "NURF complex", and the NURF name is based on this phrase. However, this phrase is equally true for CERF as it is also a "nucleosome remodeling factor complex". Not sure how best to deal with this, but wanted to point it out.

thanks,

-Karen

Discussion

  • Tanya Berardini

    Tanya Berardini - 2012-12-11
    • assigned_to: nobody --> tairtb
     
  • Tanya Berardini

    Tanya Berardini - 2012-12-11

    Could do 'nucleosome remodeling factor complex' as a broad synonym for CERF and change the type for NURF to broad as well, since there are now two.

    If that sounds fine, I'll add that new term.

    Thanks,

    Tanya

     
  • Karen Christie

    Karen Christie - 2012-12-12

    Sounds good to me.

    -Karen

     
  • Tanya Berardini

    Tanya Berardini - 2013-01-15
    • status: open --> closed-duplicate
     

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