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#6912 integral to lumenal side of endoplasmic reticulum membrane

Reactome
closed-accepted
5
2010-01-15
2010-01-13
dalloliogm
No

In GO, there is a term for 'integral to cytosolic side of ER membrane' (GO:0071458), which is for proteins and components which are integral to the membrane but exposed to the citosolic side.
However, there is not a term for the elements which are exposed to the other side of the ER membrane, the lumenal one.

Term Name:
integral to lumenal side of endoplasmic reticulum membrane

Definition:
Penetrating at least one phospholipid bilayer of the endoplasmic reticulum membrane, with the bulk of the gene product located on the side that faces the ER lumen (source: adapted from GO:0071458, switching the word "citosol" with "ER lumen". I hope it is enough)

Position in the hierarchy:
Inside integral to endoplasmic reticulum membrane (GO:0030176) along with GO:0071458

Literature:
These articles (pubmed Ids) describe proteins and glycans which should be associated with the term: 16317064 (the OST complex is composed by various proteins, some of which are integral to the lumenal side of ER membrane) 10835346 (DPM3 anchors DPM1 and DPM2 to the lumenal side of the 12200473 (all these enzymes ALG9, ALG6, ALG8, ALG12 are related to the term)
This article 18313027 describes an enzyme which switches a sugar anchored to the ER membrane from the citosolic side to the lumenal side.This entry on the reactome shows a similar reaction, in which a sugar is reorientered from the two sides of the membrane: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&FOCUS_SPECIES=Homo%20sapiens&ID=162715&
This picture: http://web.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=glyco2&part=ch8&rendertype=figure&id=ch8.f3 (taken from the book Essentials of glycobiology, http://web.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=glyco2&part=ch8\) shows the first steps in the synthesis for the N-glycosylation precursor.
This process involves a series of 14 reactions, 7 of which occur on the citosolic side of the ER membrane (in the lower part of the picture) and 7 on the lumenal side.
I can add other references if you need them.

synonyms:
- integral to lumenal side of ER membrane
- integral to ER membrane, lumenal side

Discussion

  • Midori Harris

    Midori Harris - 2010-01-14
    • assigned_to: nobody --> gomidori
     
  • Midori Harris

    Midori Harris - 2010-01-14

    Also requested by Bijay Jassal for Reactome, SF 2931961; comment copied here:

    Having a similar description to GO:0071458 (integral to cytosolic side of
    endoplasmic reticulum membrane) but with the definition something like
    "Penetrating at least one phospholipid bilayer of the endoplasmic reticulum
    membrane, with the bulk of the gene product located on the side that faces
    the lumen". I suggest the term to come under GO:0030176 : integral to
    endoplasmic reticulum membrane.

    https://sourceforge.net/tracker/?func=detail&aid=2931961&group_id=36855&atid=440764

     
  • Midori Harris

    Midori Harris - 2010-01-14
    • milestone: --> Reactome
     
  • dalloliogm

    dalloliogm - 2010-01-14

    Yes, Bijay and me are collaborating on the same project.

     
  • Midori Harris

    Midori Harris - 2010-01-15

    added integral to lumenal side of endoplasmic reticulum membrane GO:0071556

     
  • Midori Harris

    Midori Harris - 2010-01-15
    • status: open --> closed-accepted
     

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