#11818 missing links and relationships in the BDNF-TRKB receptor signalling pathway and parent

[Nancy Campbell]

Hi,

There are missing links and relationships in the Neurotrophin TRK receptor signalling pathway and Brain-derived neurotrophic factor receptor signalling pathway. I am attaching a figure of how things looks now on QuickGO.

1. Should these terms be linked?:

Process: GO:0048011 neurotrophin TRK receptor signaling pathway

A series of molecular signals initiated by the binding of a neurotrophin to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription.

and

Function: GO:0005167 neurotrophin TRK receptor binding

Interacting selectively and non-covalently with a neurotrophin TRK receptor.

1. Should these terms be linked?:

Process: GO:0031547 brain-derived neurotrophic factor receptor signaling pathway

The series of molecular signals generated as a consequence of a brain-derived neurotrophic factor receptor binding to one of its physiological ligands.

and

Function: GO:0005169 neurotrophin TRKB receptor binding

Interacting selectively and non-covalently with the neurotrophin TRKB receptor.

1. Since BDNF is a subtype of neurotrophin and TRKB is a subtype of TRK receptors, (note BDNF interacts specifically with TRKB) should

GO:0031547 brain-derived neurotrophic factor receptor signaling pathway

be a child of:

GO:0048011 neurotrophin TRK receptor signaling pathway?

PMID: 22217452 (review - figure 2)

or better suggestions

GOC: NC
GOC: BHF

Thanks

Nancy

[Nancy Campbell]

Hi David,

Me again! please let me know if I should add this as a new ticket.

I have looked at the pathway on QuickGO more closely looking for a term that describes the PLC pathway downstream of TRK the activation of which leads to the activation of PKC pathway.

I could not find such a term but I found that these two pathways (i.e. PLC and/or PKC) are defined as distinct branches for GPCR (diagram attached). I can’t comment on that but I was wondering if it is possible or even if it is necessary (your input please?) to indicate both together in one term (or separately?) that represents what I am looking for i.e. TRK-PLC-PKC e.g. PLC-activating & PKC activating TRK receptor signalling pathway.

I am attaching a diagram showing possible links for the new term. I hope this explains better my point. The graph will look slightly different if the missing links requested above are approved.

The pathways are shown in figure 2 of the paper indicated above PMID 22217452

Thanks

Nancy

[Nancy Campbell]

more recent review PMID 24860421 (figure 1)

thanks.