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#11812 Definition of GO:0072655 establishment of protein localization to mitochondrion?
I think this definition is misleading:
GO:0072655
establishment of protein localization to mitochondrion
Definition The directed movement of a protein to a specific location in the mitochondrion.
Synonyms:
exact establishment of protein localization in mitochondrion
exact establishment of protein localisation to mitochondrion
IMHO, implicit in the phrase "to a specific location in the mitochondrion" is the meaning that the protein is being moved to an (un-named) part or region of the mitochondrion. I think the desired meaning is that the protein is simply being moved to the mitochondrion, without any implication of sub-localization. I think, therefore, that it should be changed to:
"The directed movement of a protein to the mitochondrion"
Or do I misunderstand?
Hi Paul,
If you look at the children of this term, some of them specify where in the mitochondrion the localization takes place. I think the original phrasing was meant to imply that the specific location was somewhere in the mitochondrion. However, I also think that whenever the localization is in the mitochondrion it is probably not homogeneous and is in fact in a specific part. I'm willing to change the def as you suggest or perhaps even "The directed movement of a protein to the mitochondrion or a part of the mitochondrion". I am also a bit puzzled by the directed movement part of the def. As David alluded to in the other SF item, establishment of localization can take place in a number of ways; movement/transport (example axonal transport), selective stabilization or degradation (PMID:8949598), localized translation of specific mRNAs (PMID:23457718)and a new paper showing that different types of UTR's might be able to localize proteins (PMID:25896326).
-D
Dear David,
I like your revised def. "The directed movement of a protein to the mitochondrion or a part of the mitochondrion", but as you point out, these other underlying mechanisms don't use directed movement. Not sure what to suggest...David OS implies that it would involve massive rearrangement and re-annotation if this was changed.
I also thought that only the transport defs used the phrase 'directed movement'
For now I will change the def as suggested above. I think movement is correct in most but not all cases.