#11783 new term request: Formation of telomeric circles

[Nancy Campbell]

I would like to request the following term with the following suggestions or better:

suggested term: formation of telomeric circles (t-circles).

suggested definition: a process that results in the generation of duplex or single-stranded DNA circles formed from telomeric repeat sequences called telomeric circles (t-circles). T-circles are involved in the control of telomere length via alternative-lengthening of telomeres (ALT) pathway and telomere rapid deletion (TRD).

PMID: 19809492 (review)
PMID: 19858100
PMID: 19581589
PMID: 19214183

child of: GO:0000723

Thanks

Nancy

[Nancy Campbell]

forgot dbxref

GOC:NC
GOC:BHF

[Tanya Berardini]

From the review:

Telomeric circle. An extrachromosomal duplex or single-stranded circular DNA molecule composed of t-arrays.

Revised proposed term name:

t-circle formation
exact synonym: telomeric circle formation

Revised proposed definition:

A telomere maintenance process that results in the formation of a telomeric circle, or t-circle. A t-circle is an extrachromosomal duplex or single-stranded circular DNA molecule composed of t-arrays. T-circles are involved in the control of telomere length via alternative-lengthening of telomeres (ALT) pathway and telomere rapid deletion (TRD).

[Nancy Campbell]

Looks good to me. Thanks Tanya.

[Tanya Berardini]

Added:

+id: GO:0090656
+name: t-circle formation
+namespace: biological_process
+def: "A telomere maintenance process that results in the formation of a telomeric circle, or t-circle. A t-circle is an extrachromosomal duplex or single-stranded circular DNA molecule composed of t-arrays. T-circles are involved in the control of telomere length via alternative-lengthening of telomeres (ALT) pathway and telomere rapid deletion (TRD)." [GOC:BHF, GOC:nc, PMID:19214183, PMID:19581589, PMID:19809492, PMID:19858100]
+synonym: "telomeric circle formation" EXACT []
+is_a: GO:0000723 ! telomere maintenance