#11777 NTR: miRNA 2'-O-methylation

[rach_huntley]

Hi,

Could you please create a new term: "miRNA 2'-O-methylation" (equivalent to the snRNA version GO:1990437 snRNA 2'-O-methylation) as a child of GO:0001510 RNA methylation and GO:0010586 miRNA metabolic process (note: there is a term GO:0044747 mature miRNA 3'-end processing, but the definition is "Any process involved in forming distinct miRNA isoforms from a mature miRNA that differ at their 3'-ends" -- I don't think is applicable to my requested term as it's not creating a new isoform).

Suggested definition: The posttranscriptional addition of a methyl group to the 2' oxygen atom of a nucleotide residue in an miRNA molecule.

Reference: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2941102/

Please add GOC:BHF_miRNA and GOC:rph

Thanks,
Rachael.

[David Hill]

[Term]
+id: GO:0061715
+name: miRNA 2'-O-methylation
+namespace: biological_process
+def: "The posttranscriptional addition of a methyl group to the 2' oxygen atom of a nucleotide residue in an miRNA molecule." [GOC:BHF_miRNA, GOC:rph, PMID:20705645]
+is_a: GO:0001510 ! RNA methylation
+is_a: GO:0010586 ! miRNA metabolic process
+created_by: dph
+creation_date: 2015-06-29T08:41:03Z

Maybe reposition as a child of 'primary miRNA methylation'?

-D

[rach_huntley]

Hi David,

"Maybe reposition as a child of 'primary miRNA methylation'?"

I don't think this would be appropriate as the methylation is happening to the mature miRNA rather than the primary miRNA precursor.

Thanks,
Rachael.