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#11472 NTR: mRNA cleavage involved in gene silencing by siRNA

BHF-UCL
closed-accepted
Tanya Berardini
miRNA (10) New term request (5530)
5
2015-01-22
2015-01-19
rach_huntley
No

NTR: mRNA cleavage involved in gene silencing by siRNA
Def: The process in which small interfering RNAs (siRNAs) direct the cleavage of target mRNAs. Once incorporated into a RNA-induced silencing complex (RISC), a siRNA will typically direct cleavage by base pairing with perfect or near-perfect complementarity to the target mRNA.

as an equivalent to GO:0035279 mRNA cleavage involved in gene silencing by miRNA

PMID:15260970

Please add db_xrefs GOC:BHF_miRNA and GOC:rph.

Thanks,
Rachael.

Discussion

  • rach_huntley

    rach_huntley - 2015-01-19
    • Description has changed:

    Diff:

    --- old
+++ new
@@ -1,4 +1,3 @@
-
 NTR: mRNA cleavage involved in gene silencing by siRNA 
 Def: The process in which small interfering RNAs (siRNAs) direct the cleavage of target mRNAs. Once incorporated into a RNA-induced silencing complex (RISC), a siRNA will typically direct cleavage by base pairing with perfect or near-perfect complementarity to the target mRNA.
    • Group: None --> BHF-UCL
     

  • Tanya Berardini

    Tanya Berardini - 2015-01-21
    • labels: miRNA --> miRNA, New term request
    • assigned_to: Tanya Berardini
     

  • Tanya Berardini

    Tanya Berardini - 2015-01-22
    • status: open --> closed-accepted
     

  • Tanya Berardini

    Tanya Berardini - 2015-01-22

    Added:

    [Term]
    +id: GO:0090625
    +name: mRNA cleavage involved in gene silencing by siRNA
    +namespace: biological_process
    +def: "The process in which small interfering RNAs (siRNAs) direct the cleavage of target mRNAs. Once incorporated into a RNA-induced silencing complex (RISC), a siRNA will typically direct cleavage by base pairing with perfect or near-perfect complementarity to the target mRNA." [GOC:BHF_miRNA, GOC:rph, PMID:15260970]
    +is_a: GO:0006379 ! mRNA cleavage
    +intersection_of: GO:0006379 ! mRNA cleavage
    +intersection_of: part_of GO:0016246 ! RNA interference
    +relationship: part_of GO:0016246 ! RNA interference

     

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