Hi, Could I please request a term for the Vps4-Vta1 Complex?
Vps4-Vta1 Complex
Synonyms: Vta1-Vps4 Complex, Vps4 Complex
Def: The Vps4-Vta1 Complex is an oligomeric assembly of the AAA-ATPase Vps4 and its cofactor Vta1 and is involved in ESCRT-mediated intralumenal vesicle formation. The complex catalyzes disassembly of the ESCRT-III filament around the neck of the budding vesicle in an ATP-driven reaction, resulting in membrane scission and recycling of the ESCRT-III components back to the cytosol.
Refs: PMID:20653365 (The ESCRT complexes. 2010)
PMID:20696398 (Structural role of the Vps4-Vta1 interface in ESCRT-III recycling. 2010)
PMID:25164817 (Vps4 Stimulatory Element (VSE) of the Cofactor Vta1 Contacts the ATPase Vps4 α7 and α9 to Stimulate ATP Hydrolysis.)
Thanks
Diff:
Hi Helen,
Thanks for waiting! I'd add your requested term as follows, please let me know if you disagree with any of it:
GO:NEW Vps4-Vta1 complex
is_a protein complex
part_of GO:0010008 endosome membrane
capable_of_part_of GO:0070676 intralumenal vesicle formation
A protein complex involved in ESCRT-mediated intralumenal vesicle formation. The complex catalyzes disassembly of the ESCRT-III filament around the neck of the budding vesicle in an ATP-driven reaction, resulting in membrane scission and recycling of the ESCRT-III components back to the cytosol. In yeast, it is formed by the AAA ATPase Vps4 and its cofactor Vta1.
GOC:ha, PMID:20653365, PMID:20696398, PMID:25164817
Synonyms: Vta1-Vps4 complex (exact), Vps4 complex (broad)
Thanks,
Paola
Thanks, Paola. It's all lovely!
Regards,
Helen
On 27 Jan 2015, at 12:04, Paola Roncaglia wrote:
Related
Ontology requests:
#11134Thanks Helen.
Here’s your term below. Should you need similar ones in the future, you could submit them via TG freeform (which has a field for capable_of_part_of process links). There’s also a regular TG template for protein complexes that have a capable_of function link. I was happy to add this one for you as you’d already waited some time, so no prob!
Any question on TG, please feel free to ask. Have a good day,
Paola
[Term]
id: GO:1990621
name: Vps4-Vta1 complex
namespace: cellular_component
def: "A protein complex involved in ESCRT-mediated intralumenal vesicle formation. The complex catalyzes disassembly of the ESCRT-III filament around the neck of the budding vesicle in an ATP-driven reaction, resulting in membrane scission and recycling of the ESCRT-III components back to the cytosol. In yeast, it is formed by the AAA ATPase Vps4 and its cofactor Vta1." [GOC:ha, PMID:20653365, PMID:20696398, PMID:25164817]
synonym: "Vps4 complex" BROAD []
synonym: "Vta1-Vps4 complex" EXACT []
is_a: GO:0043234 ! protein complex
relationship: capable_of_part_of GO:0070676 ! intralumenal vesicle formation
relationship: part_of GO:0010008 ! endosome membrane
created_by: pr
creation_date: 2015-01-29T10:02:30Z