#11107 NTR: children to GO:0007269 neurotransmitter secretion

[Paul Denny]

GO:0007269 neurotransmitter secretion
can be evoked by an action potential or occur spontaneously without electrical or chemical stimulation - both are described in the literature and in PMID: 21334193
the case is made that “spontaneous and evoked neurotransmission comprise independent neuronal signal transduction pathways that may operate in a spatially segregated manner”.

Many neurophysiological studies talk separately about each mode of secretion / release, so I think we need child terms to GO:0007269 neurotransmitter secretion such as:

1) spontaneous neurotransmitter secretion
2) evoked neurotransmitter secretion

Thanks,
Paul

[Paul Denny]

HI David - how is this NTR progressing?
Cheers

[David Hill]

Hi Paul,

Sorry it took so long.

[Term]
+id: GO:0061669
+name: spontaneous neurotransmitter secretion
+namespace: biological_process
+def: "Neurotransmitter secretion that occurs in the absence of the action of a secretagogue or a presynaptic action potential." [GOC:dph, GOC:pad, GOC:PARL, PMID:21334193]
+synonym: "stimulus-independent neurotransmitter secretion" EXACT [GOC:dph]
+is_a: GO:0007269 ! neurotransmitter secretion
+created_by: dph
+creation_date: 2014-11-17T07:52:35Z
+
+[Term]
+id: GO:0061670
+name: evoked neurotransmitter secretion
+namespace: biological_process
+def: "Neurotransmitter secretion that occurs in the presence of the action of a secretagogue or a presynaptic action potential." [GOC:dph, GOC:pad, GOC:PARL, PMID:21334193]
+synonym: "stimulus-dependant neurotransmitter secretion" EXACT [GOC:dph]
+is_a: GO:0007269 ! neurotransmitter secretion
+created_by: dph
+creation_date: 2014-11-17T08:06:21Z

Let me know if you see anything that looks off.

-D

[Paul Denny]

No worries, thanks.
Paul