I am reading a paper on replication fork stalling, so I started looking at the child terms to "replication fork processing" (there aren't very many).
I was slightly unsure what this term meant: GO:0071932 replication fork reversal
but on a closer look I think this looks like a phenotype?
From the paper cited as a ref: rad53 mutants exhibit extensive single-stranded gaps and hemi-replicated intermediates, consistent with a lagging-strand synthesis defect. Further, rad53 cells accumulate Holliday junctions through fork reversal. We speculate that, in checkpoint mutants, abnormal replication intermediates begin to form because of uncoordinated replication and are further processed by unscheduled recombination pathways, causing genome instability.
In the paper that I am reading right now, the authors say that normally when a fork is stalled, proteins act to protect the fork to prevent its collapse. If a fork does collapse, the fork may be restarted via homologous recomb but this is error prone and can lead to genomic instability.
So I guess in the ref for GO:0071932, replication fork stalling is abnormal, so they collapse and this leads to genomic instability? Does this sound right?
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