#10772 ntr: isogloboside biosynthetic process

[Karen Christie]

Hi,

I was making some annotations from PMID:22875802 (citation below) and I would like a term for "isogloboside biosynthetic process" as an is_a child of GO:0006688 - glycosphingolipid biosynthetic process. Presumably it would make sense to have the metabolic process and catabolic process terms also.

We already have a term for "globoside biosynthetic process", but apologies, my chemistry isn't good enough to suggest how to modify this to get the right core structure for the isogloboside.

The paper listed below has a nice diagram about which enzymes are involved with various steps of glycosphingolipid metabolism, but I see anything that helped me know how to write the formal name of the isoglobosides..

thanks,

-Karen

Porubsky S, Speak AO, Salio M, Jennemann R, Bonrouhi M, Zafarulla R, Singh Y,
Dyson J, Luckow B, Lehuen A, Malle E, Müthing J, Platt FM, Cerundolo V, Gröne HJ.
Globosides but not isoglobosides can impact the development of invariant NKT
cells and their interaction with dendritic cells. J Immunol. 2012 Sep
15;189(6):3007-17

[Karen Christie]

actually, maybe I need this term:

"isogloboside biosynthetic process via lactosylceramide"

thanks,

-Karen

[Chris Mungall]

Shouldn't this be a CHEBI request?

[David Hill]

Assigning to Harold so that he can request the chemical from chebi if necessary.

[Harold J. Drabkin]

CHEBI:78257 requested

[Harold J. Drabkin]

use these PMIDs also for structures
PMID:18810447
and
PMID:18630988

[Harold J. Drabkin]

the globoside biosynthesis and isogloboside biosynthesis will be sibs; both start with lactosyl ceramide then diverge depending upon what enzyme is used next.

[Harold J. Drabkin]

Crated GO:1990387 Label: isogloboside biosynthetic process vis term genie