#10763 NTR: pri-miRNA transcription from RNA polymerase II promoter

[KM Van Auken]

Hi,
I'd like to request a new BP term, pri-miRNA transcription from RNA polymerase II promoter and the corresponding regulation terms.

GO:0006366 transcription from RNA polymerase II promoter
is_an GO:new pri-miRNA transcription from RNA polymerase II promoter
regulates GO:new regulation of pri-miRNA transcription from RNA polymerase II promoter
positively regulates GO:new positive regulation of pri-miRNA transcription...
negatively regulates GO:new negative regulation of pri-miRNA transcription...

Possible definition:
The cellular synthesis of primary microRNA (pri-miRNA) transcripts from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. pri-miRNA transcripts are subsequently processed to produce the ~22nt miRNAs that function in gene silencing.

PMID:18778799
http://en.wikipedia.org/wiki/MicroRNA

For regulation terms: PMID:24699545

Thanks,
--Kimberly

[David Hill]

Added the primary term. I will add the regulation terms via termgenie.

[Term]
+id: GO:0061614
+name: pri-miRNA transcription from RNA polymerase II promoter
+namespace: biological_process
+def: "The cellular synthesis of primary microRNA (pri-miRNA) transcripts from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. pri-miRNA transcripts are subsequently processed to produce the ~22nt miRNAs that function in gene regulation." [GOC:dph, GOC:kmv, PMID:18778799]
+is_a: GO:0006366 ! transcription from RNA polymerase II promoter
+created_by: dph
+creation_date: 2014-04-08T08:42:54Z

[David Hill]

Regulation terms added via termgenie.GO:1902893, 94 and 95.