#10749 NT: Archaeosine synthase activity & add to def of archaeosine-tRNA biosynthetic process

[Chris Mungall]

1. NT: https://en.wikipedia.org/wiki/Archaeosine_synthase

2. Add a starts_with from

id: GO:0002927
name: archaeosine-tRNA biosynthetic process

There is a case for adding this to the N+S conditions, to justify the SubClassOf tRNA modification GCI

1. Annotate arcS to this step http://amigo2.berkeleybop.org/cgi-bin/amigo2/amigo/gene_product/UniProtKB:Q58428

[Harold J. Drabkin]

Just noticed this.
I think 7-cyano-7-deazaguanine tRNA-ribosyltransferase activity, GO:0043867, is this and thus I can just add Archaeosine synthase activity as an activity.

[Harold J. Drabkin]

Ok, I now see that no, they are not the same. The one you are requesting is a step after (ie, once the 7-cyano, etc is IN the tRNA, THEN, the glutamine is used by archaeosine synthase (AS to make archaseosine in the tRNA.
So actually, this one should not get the start, but GO:0043867
so 1. nt request, but 2. add start with GO:0043867 to GO:0002927

[Harold J. Drabkin]

Added NT archaeosine synthase activity GO:0002948

[Harold J. Drabkin]

Added x-product of GO:0043967 to GO:0002927

[Chris Mungall]

Thanks harold.

So it is also valid to add a has_part to your new archaeosine synthase activity class?

(I think this should go in as a relationship, not part of the equivalence axiom)

[Harold J. Drabkin]

done;