#10734 NTR: regulation of membrane permeability

[KM Van Auken]

Hi,

I'd like to request a new child term of regulation of biological quality:

GO:0065008 regulation of biological quality
is_a GO:new regulation of membrane permeability
is_a GO:0097213 regulation of lysosomal membrane permeability
is_a GO:0046902 regulation of mitochondrial membrane permability

I'd like to use this term to describe the activity of pore-forming molecules that alter membrane permeability.

The old MF term of pore-forming toxin activity is now obsolete, so I'm trying to describe, on a more molecular level, how some pore-forming molecules with antibacterial activity actually function. I'm not sure that there's an existing MF term that can be used to describe this type of activity.

Also, I had looked at TermGenie to see if there was a possible template for this kind of term (regulation + PATO term + GO CC term) but didn't see one - let me know if I missed it.

Here is the paper I'm trying to annotate:
http://www.ncbi.nlm.nih.gov/pubmed/22677064

Thanks,
--Kimberly

[Tanya Berardini]

Added:

[Term]
+id: GO:0090559
+name: regulation of membrane permeability
+namespace: biological_process
+def: "Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by a membrane." [GOC:kmv, PMID:22677064]
+is_a: GO:0065008 ! regulation of biological quality
+created_by: tanyaberardini
+creation_date: 2014-03-27T13:48:35Z

Also moved
GO:0097213 regulation of lysosomal membrane permeability
GO:0046902 regulation of mitochondrial membrane permability

to be children of this new term.