#10666 dendritic filopodium - child to GO:0030425 dendrite

[Paul Denny]

dendritic filopodium - child to GO:0030425 dendrite as part_of
also
is_a
GO:0044463 cell projection part
Would need to be restricted by taxon? Or not (?) because it's parents e.g. GO:0097458 neurone part - already are.
PMID:24464040
Definition: small, membranous protrusions found primarily on dendritic stretches of developing neurons.
http://en.wikipedia.org/wiki/Dendritic_filopodia
GOC:PARL
GOC:pd

[Paola Roncaglia]

Hi Paul, welcome to SF!

Before I forget -
The 'Labels' field may be used to indicate if your request is about a new term ("New term request"), or about making changes to existing terms ("Other term request"). It may also be used to indicate a specific ontology development topic, e.g. 'Apoptosis' or 'Cell cycle'. I've changed the Label for this request to 'new term request'.

Cheers,
Paola.

[Paul Denny]

Thanks Paola,
I don't think this should be a child term of GO:0030175 filopodium
because in PMID: 12904473 (cited in http://en.wikipedia.org/wiki/Dendritic_filopodia) it suggests there are at least two distinct types of filopodium.

[Paola Roncaglia]

Hi Paul,

As for your comment:

I don't think this should be a child term of GO:0030175 filopodium
because in PMID: 12904473 (cited in http://en.wikipedia.org/wiki/Dendritic_filopodia) it suggests there are at least two distinct types of filopodium.

We can solve this by making the existing term GO:0030175 filopodium more general. I've edited its definition, from the old
"Thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone; usually approximately 0.1 um wide, 5-10 um long, can be up to 50 um long in axon growth cones; contains a loose bundle of about 20 actin filaments oriented with their plus ends pointing outward."
to the new
"Thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft."
and I've added a definition comment:
"A filopodium may be approximately 0.1 um wide, 5-10 um long, and up to 50 um long in axon growth cones; may contain a loose bundle of about 20 actin filaments oriented with their plus ends pointing outward. Note that filopodia on dendritic shafts are distinct from other types of filopodia (even those found in dendritic growth cones) and may react differently to stimuli, as shown in PMID:12904473."

Then I'll add this new term for you, and will post the GO ID here as soon as it's live:

GO:NEW dendritic filopodium
is_a filopodium
part_of GO:0030425 dendrite
A small, membranous protrusion found primarily on dendritic stretches of developing neurons. May receive synaptic input, and can develop into dendritic spines.
def. comm.: Dendritic filopodia are generally less-well studied than dendritic spines because their transient nature makes them difficult to detect with traditional microscopy techniques, and because they are sometimes destroyed by sample preparation. Note that filopodia on dendritic shafts are distinct from other types of filopodia (even those found in dendritic growth cones) and may react differently to stimuli, as shown in PMID:12904473.
PMID:24464040, GOC:PARL, GOC:pd, http://en.wikipedia.org/wiki/Dendritic_filopodia
exact synonym: dendrite filopodium

As for your question

Would need to be restricted by taxon? Or not (?) because it's parents e.g. GO:0097458 neurone part - already are.
The latter is correct. Terms automatically inherit taxon restrictions from their parent(s), so no need to add one here.

Thanks,
Paola

[Paola Roncaglia]

Paul emails:

"Thanks Paola,
Excellent resolution!
Best,

Paul"

[Paola Roncaglia]

Note for self: all that's left to do is commit the TG term and post its ID/name here.

[Paola Roncaglia]

Hi Paul,

Your new term is ready to use:

id: GO:1902737
name: dendritic filopodium

Thanks,
Paola