The authors show that the B subtilis DNA translocase SpoIIIE acts as a "wire stripper" to remove proteins from DNA as it transports DNA from the mother cell to the forespore. I'm thinking this might represent a class of activities, and terms could be vlable for capturing disinctions between proteins that are or are not blocked in their movement on nucleic acids by protein roadblocks. I think there are three things that can happen
- the moving protein is roadblocked
- the moving protein displaces the roadblock
- the moving protein bypasses the roadblock
I believe all three have been observed for translocases, helicases, and polymerases.
A problem I see is that some proteins may act differently depending on the nature of the roadblock.
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