#541 PKA regulatory subunit maps to 'kinase activity' in spkw2go

[Doug Howe]

The cAMP-dependent protein kinase regulatory subunit alpha b in ZFIN (prkar2ab) is mapped via spkw2go (SP_KW:KW-0418) to GO:0016301 'kinase activity'. The regulatory subunits of protein kinase A (in any species) do not have kinase activity themselves...they regulate the kinase activity inherent in the PKA catalytic subunits.

The proper mapping might be 'regulation of kinase activity' (GO:0043549)

-Doug

[Doug Howe]

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Note this is a process mapping replacing the existing function mapping for this SPKW. I can't think of a good function mapping for this domain.

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I also see that our prkar2ab gene is mapped to 'protein amino acid phosphorylation' by interpro2go mapping from:
IPR002373
IPR012198
Like the above function issue, this mapping could be made more specific (at least for fish vertebrate PKA R subunits) if it were mapped to GO:0001932: regulation of protein amino acid phosphorylation. Though the current mapping of these two IPR IDs isn't incorrect, it is less specific than it could be perhaps?

[Midori Harris]

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Hi Doug,

I'm going to move these questions to the annotation tracker, and create a new item for the interpro2go one (spkw2go and interpro2go items get assigned to different people).

midori

[Valerie Wood]

Hi Doug,

Did this get fixed?

Cheers

Val

[rach_huntley]

Q6NW93 still has two GO annotations derived from KW-0418.
Have submitted to the UniProt helpdesk.