The packages used in the GEMMA data analysis
| Description | Package | Version |
|---|---|---|
| Data import | GEOquery | 2.52.0 |
| Batch correction | Sva (ComBat) | 3.32.1 |
| Preprocessing, normalization, statistical analysis | Limma | 3.40.6 |
| Preprocessing, normalization | Minfi | 1.30.0 |
| GC-correction | ArrayTV | 1.22.0 |
| Segmenting copy number data | DNAcopy | 1.58.0 |
| Copy number calling | CNVkit (Python) | 0.9.6 |
| Genome sequences | BSgenome.Hsapiens.UCSC.hg18 | 1.3.1 |
| Coordinate liftover | Rtracklayer | 1.44.4 |
| Annotation | annotatr | 1.10.0 |
| Annotation | Org.Hs.eg.db | 3.8.2 |
| Illumina identifiers | lumiHumanIDMapping | 1.10.1 |
| Identify Methylated Regions | DMRcate | 1.20.0 |
| Venn diagram -visualization | VennDiagram | 1.6.2 |
| Summarizing copy number data | CNVRanger | 1.0.3 |
| Visualize copy number data | GenVisR | 1.16.1 |
| Representation of genomic intervals | GenomicRegions | 1.36.1 |
| Data integration | MixOmics | 6.8.5 |
| Pathway analysis | ReactomePA | 1.28.0 |
| Gene set enrichment analysis | gage | 2.34.0 |
| Visualizing intersections | VennDiagram | 1.6.20 |
| Enrichment visualizations | enrichplot | 1.4.0 |
| Gene relevance based on multiple evidences in complex networks: https://www.itb.cnr.it/mnd | ||
| [Snippets] |
PRS construction
PRS-CS |https://github.com/getian107/PRScs| infers posterior SNP effect sizes under continuous shrinkage (CS) priors using GWAS summary statistics and an external LD reference panel
PLINK2