RealdataSimu

Simulation for case-control data and quantitative traits using real GWAS data

Simulating quantitative traits

Master option
--bsimu

Options
--bfile
Specify the gwas data in binary format

--simu-rep
Specify the replication. By default, only 1 replication will be generated.

--simu-hsq
Specify the heritability. By defualt, heritability is 0.5.

--simu-causal-loci
Specify the file which contains the list for causal snps. One snp per line.

--simu-rnd-causal-loci
Alternatively, it can specify the number of causal loci. By default, all markers will be causal, a typical polygenic model.

Examples

~~~~~
gear --bsimu --bfile test --simu-rep 10 --simu-hsq 0.25 --simu-causal-loci loci.txt --out test
gear --bsimu --bfile test --simu-rep 10 --simu-hsq 0.25 --simu-rnd-causal-loci 100 --out test
~~~~~~~~