Basically selenocysteine should react with the same thiol blocking groups as cysteine. I'm assuming that we can just add +57 to U.
This change has already been made to Comet:
http://sourceforge.net/p/comet-ms/code/886/
Here is a relevant paper:
http://dx.doi.org/10.1021/acs.jproteome.5b01028
Log in to post a comment.