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ClinStudyWeb is designed to provide a flexible infrastructure for managing patient and assay data from clinical studies. It uses a plugin system for study-specific web forms and arbitrarily complex test classifiers, and supports XML import/export.

Project Admins:

• Tim Rayner

[Tim Rayner]

Welcome to ClinStudyWeb

This is the main wiki for the ClinStudyWeb project.

Introduction

The purpose of the ClinStudyWeb project is to develop a distributable database system for tracking clinical study data in a disease-agnostic fashion. The system is designed to integrate clinical data with high-throughput genomic technologies such as gene expression or genotyping microarrays.

Features

• Written, tested and maintained as part of a clinical study investigating both rare and prevalent autoimmune diseases, the ClinStudyWeb system has demonstrated its adaptability to complex real-world clinical research environments.

• By using a generic database schema ClinStudyWeb provides a flexible semantic framework within which patient data from many different concurrent clinical studies may be managed.

• Data transfer between multiple clinical sites is facilitated by a well-defined XML data exchange format.

• ClinStudyWeb includes an extensible modular architecture designed to simplify the acquisition, storage and querying of complex clinical test
  results and classification scores.

• Easy management of patient data using a secure web interface built using MVC design principles.

• Fully automated audit history for all data entered via web interface or command-line scripts.

• Secure programmatic interface via a built-in REST-based API.

• Full integration with the R statistical programming language and the data analysis packages provided by the Bioconductor project.

• MIAME-supportive export of data in MAGE-TAB format (v1.1), ready for submission to international data repositories as part of the publication process.

Documentation

1. [Installation]
2. [Database Administration]
3. [Default User Accounts]
4. [ClinStudyML Data Exchange Format]
5. [Tab-Delimited Data Formats]
6. [MAGE-TAB export]
7. [Semantic Frameworks]
8. [Study-Specific Data Entry]
9. [Aggregate Test Result Calculation]
10. [Code Architecture]
11. [Database Schema]
12. [Audit History]
13. [Programmatic JSON query API]