#33 2-oxoglutarate really a cofacotr?

[Julia Fischer]

CHEBI:16810 2-oxoglutarate(2−) is an is_a child of entity "cofactor", with unvalidated relationship status. I couln't find any evidence for that in the literature. The only thing I found in publication 15948966 was

"The α-KG-dependent dioxygenases use one atom of the oxygen molecule to oxidize a specific substrate while the second atom oxidizes a co-substrate (α-KG) to succinate".

If it turns out that there is no evidence for 2-oxogluterate(2-) ans (1-), please delete the relationships to cofactor.

Thank you!

[Kirill Degtyarenko]

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Since 2-oxoglutarate is converted to succinate, it should be rather classified as "coenzyme". Do you agree with that?
Since 2-oxoglutarate does coodinate the active site Fe(II) in bidentate mode (using 2-oxo group and one carboxylic oxygen), at least one (coordinating) carboxylic group is deprotonated. Therefore it is either 2-oxoglutarate(1−) or 2-oxoglutarate(2−).

Kirill