#29 vitamin c

[Julia Fischer]

Vitamin C (ascorbic acid, CHEBI:29073 and ascorbate, CHEBI:38290) are (non-validated) children of cofactor. They are not prsthetic groups but used to reduce oxidized sites in other prsthetic groups (ref: 2057141, last sentence), which means it must go in and out of active sites. Therefore I suggest to either create a head entity (e.g. vitamin c) with children 29073 and 38290 and make it a child of coenzyme, or to shift the two entities directly under coenzyme.

[Ian Unwin]

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A heading for vitamin C is also needed from the nutritional point-of-view; it will also include L-dehydroascorbic acid. Thus the hierarchy should be:
-water-soluble vitamin (CHEBI:27314)
--vitamin C
---L-ascorbic acid (CHEBI:29073)
---L-dehydroascorbic acid (CHEBI:27956)

A question arises over whether L-ascorbate should also be a child of vitamin C. It might be better to rely on the relation:
L-ascorbate (CHEBI:38290) is conjugate base of L-ascorbic acid (CHEBI:29073)
to reflect this, because the direct children of a vitamin entity should perhaps be restricted to the separate contributors to the vitamin activity. Addition of the vitamin heading could allow the inexact synonym of 'Vitamin C' under L-ascorbic acid to be removed.

[Kirill Degtyarenko]

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I have created the following relationships:

vitamin C (CHEBI:21241) is a water-soluble vitamin (CHEBI:27314)
L-ascorbic acid (CHEBI:29073) is a coenzyme (CHEBI:23354)
L-ascorbic acid (CHEBI:29073) is a vitamin C (CHEBI:21241)
L-dehydroascorbic acid (CHEBI:27956) is a coenzyme (CHEBI:23354)
L-dehydroascorbic acid (CHEBI:27956) is a vitamin C (CHEBI:21241)

I have removed relationships from CHEBI:29073 and CHEBI:38290 to cofactor.

Kirill