expression_mut

[Instructions]

Find which genes with expression levels statistically different between groups defined by mutation status.

If you divide samples into two groups by mutation status of a gene, find the genes that are most different by t-test.

For each gene with expression data, do a t-test and record the t-statistic.
Return the ranked list of genes sorted by abs(t-statistic).
A heatmap of expression clustered by mutation status is automatically generated. Yellow bar = mutated sample. Green bar = non-mutated sample.

Include mutations : if checked, only use mutations to determine groups. (ie. exclude fusions)
Include fusions : if checked, use only fusions to determine groups. (ie. exclude mutations)
(if both are checked, or none are checked then mutations and fusions will be used)
num results : the number of results to return (default 25)

HUGO : enter gene symbol here. (required)
EXPRESSION : expression source (required)
MUTATION : mutation source (required)

example Query: MUTATION = TCGA-LUAD, EXPRESSION = TCGA-LUAD-RSEM, HUGO = EGFR