Home

Stuart Aitken
Attachments
infer.png (442727 bytes)

Dizzy-Beats is a graphical Java application downloadable from this website (see the Files tab) that builds on the established Dizzy simulator http://magnet.systemsbiology.net/software/Dizzy/ We add an optimisation function based on simulated annealing, and nested sampling for computing the Bayesian Evidence and the moments of parameter posteriors. Dizzy-Beats supports model comparison through calculation of log Z (log Bayesian Evidence) for a model and replicate time series data. The methodology is described further here: http://www.biomedcentral.com/1752-0509/7/72

mRNA expression

In common with all comparable probabilistic approaches, a likelihood function is required to calculate the probability of the data given the model parameters, and here we take a novel approach by adopting a likelihood based on the l1-norm. This function is applicable to any replicated time series data, giving a likelihood that reflects biological variability rather than assumed Gaussian technical error. The Dizzy-Beats application runs on the most common operating systems and is open source.


Want the latest updates on software, tech news, and AI?
Get latest updates about software, tech news, and AI from SourceForge directly in your inbox once a month.