AmPEP and AxPEP

Antimicrobial peptides (AMPs) are promising candidates in the fight against multidrug-resistant pathogens due to its broad range of activities and low toxicity. However, identification of AMPs through wet-lab experiment is still expensive and time consuming. AmPEP is an accurate computational method for AMP prediction using the random forest algorithm. The prediction model is based on the distribution patterns of amino acid properties along the sequence. Our optimal model, AmPEP with 1:3 data ratio achieved a very high accuracy of 96%, MCC of 0.9, AUC-ROC of 0.99 and Kappa statistic of 0.9. AmPEP outperforms existing methods with respect to accuracy, MCC, and AUC-ROC when tested using the benchmark datasets.
Server online at https://cbbio.online/AxPEP