APPRIS

APPRIS is a pipeline that deploys a range of computational methods to provide value to the annotations of the human genome. APPRIS also selects one of the CDS for each gene as the principal functional isoform.

Recent studies have estimated that almost 100% of multi-exon human genes produce differently spliced mRNAs. It is important to designate one of the isoforms as the "principal" functional isoform in order to predict changes in function, structure or localisation brought about by alternative splicing. APPRIS defines the principal variant by combining protein structural and functional information and information from the conservation of related species.

The server is being used in the context of the scale up of the ENCODE project to annotate the human genome.