It seem impossible for Anaphraseus to handle very large TMs. I tried to load a TM with 80000 TUs and it wouldn't even load. Even if TMs with more than 10000 TUs can be loaded, changing TMs for different projects would be very slow.
I wonder if it is possible to store the TM with MySQL or similar database servers. That would not only give Anaphraseus multiuser capabilities, it should also improve performance significantly.
Possibly, this could be done using Openoffice Base which supports MySQL.