https://sourceforge.net/p/altanalyze/wiki/RMA/Recent changes to RMAenSat, 01 Feb 2014 01:06:34 -0000https://sourceforge.net/p/altanalyze/wiki/RMA/<div class="markdown_content"><h1 id="introduction">Introduction</h1> <p>RMA or <a class="" href="http://www.ncbi.nlm.nih.gov/pubmed/12925520" rel="nofollow">Robust MultiArray Average</a> is a method commonly used for microarray summarization and normalization. RMA is the default method using by <a class="" href="/p/altanalyze/wiki/AltAnalyze/">AltAnalyze</a> for Affymetrix microarray expression normalization. To do this, <a class="" href="/p/altanalyze/wiki/AltAnalyze/">AltAnalyze</a> calls an imbedded version of the Affymetrix software <a class="" href="../APT">APT</a>. The result of RMA are sample expression values with a near identical distribution of expression values. APT also produces detection above background (DABG) p-values, for all Affymetrix arrays, to determine if a particular probeset is reasonably expressed (e.g. Present or Absent). </p> <h1 id="details">Details</h1> <p><a href="http://www.plexdb.org/modules/documentation/RMAexplained.pdf" rel="nofollow">http://www.plexdb.org/modules/documentation/RMAexplained.pdf</a></p></div>AnonymousSat, 01 Feb 2014 01:06:34 -0000https://sourceforge.net363eddc58d58feea0efed5348c7c91d372f361bf