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clusterProfiler is an R/Bioconductor package that provides a unified workflow for functional enrichment analysis to interpret high-throughput omics results. It supports both over-representation analysis and gene set enrichment analysis, letting you work with unranked gene lists or ranked statistics from differential pipelines. The package connects to multiple knowledge bases—such as Gene Ontology, KEGG, Reactome, Disease Ontology, MeSH and others—through a consistent interface so you can query different biological lenses without rewriting code. It is designed for breadth, covering coding and non-coding features and thousands of organisms by leveraging continuously updated annotations. Results are returned in tidy, manipulation-friendly structures and pair naturally with rich visualization functions (via companion tooling) to summarize pathways, terms, and gene–set relationships.
Features
- Unified ORA and GSEA workflows across multiple annotation sources
- Broad species support using up-to-date gene annotations
- Tidy outputs that integrate cleanly with downstream R data pipelines
- Built-in visualization of enrichment results through companion plotting tools
- Multi-group comparison utilities (e.g., compareCluster) for cross-condition analysis
- Detailed vignettes and manuals for reproducible, end-to-end enrichment studies
Project Samples
