I experienced the crash at start problem using notepad++ v4.1.2 - I fixed this by deleting a line in session.xml:

        <File firstVisibleLine="0" xOffset="0" startPos="0" endPos="10">new 3</File>

I had to other real files called "new 3" already - so I think it might be some correlation there - if I edit "new 3" to "new 9" notepad++ does not crash. If you do not want to edit the file you may delete the whole session.xml - it only contains information about which files should be automatically reopened. This will not delete any other configuration data.

Session.xml is found in %appdata% and notepad++ folder. Just press start run and write %appdata% to find it - it should be located in a subfolder called notepad++.