Search Results for "protein" - Page 3
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Showing 363 open source projects for "protein"
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CusVarDB
CusVarDB generated variant protein database from NGS-datasets
CusVarDB is a windows based tool for creating a variant protein database from Next-generation sequencing datasets. The program supports variant calling for Genome, RNA-Seq and ExomeSeq datasets. The program performs mainly 4 modules 1. Align the datasets with reference database 2. Perform the variant calling using Genome Analysis Toolkit (GATK) 3. Annotate the variant using ANNOVAR 4. Create the variant protein database Apart from the main modules, the program also supports... -
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MSIGNET
A Bayesian approach for disease-associated gene network identification
MSIGNET integrates disease-specific gene expression data and human protein-protein interactions in a Bayesian network, and identifies interactions of genes significantly expressed under the disease condition. -
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seqdiva
SeqDivA:Sequence Diversity Analysis
Sequence Diversity Analysis - SeqDivA version 1.0 is a python-based tool with a friendly GUI designed for Linux and Mac OS. Utility: Run alignment algorithms (water, needle, and blast) to compare all-vs.-all protein, DNA, and RNA sequences. SeqDivA provides similarity, identity, and bit-score matrixes and dot plots to explore/illustrate the diversity (homology degree) of the sequences, enabling the delimitation of the twilight zone. Installation: - Download SeqDivA... -
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SVPhylA
SVPhylA: Sequence Vectorization for Phylogenetic Analyses
SVPhylA is a python tool for the calculation of several alignment-free distances for phylogenetics analysis from the most popular alignment-free approaches. Such alignment-free methods basically encode DNA and protein sequences (fasta files) into numerical vectors allowing the calculation of alignment-free distances which may be combined into a consensus/compromise matrix by using algorithms like DISTATIS based on Multidimensional Scaling (MSD), Lineal Principal Component Analysis (PCA) and PCA... -
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Zehnhoch3
Program that simulates evolution of a small protein.
Program that simulates evolution of a small protein. -
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PPIXpress
specific protein interaction networks from transcript expression
Although protein-protein interaction networks are an ubiquitous component of modern systems biology, comparatively few efforts have been made to tailor their topology to the actual cellular condition under study. Since a simple reduction of the networks to the subset of expressed genes only scratches the surface of higher organisms’ regulatory capabilities, we propose the advanced method PPIXpress that allows to exploit expression data at the transcript-level and is thus able to also reveal... -
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MetaPA is a de Bruijn graph algorithm to obtain complete protein coding genes by assembling metagenomic and metatranscriptomic short reads. Jiemeng Liu*, Qichao Lian*, Yamao Chen, Ji Qi. (2019) Amino acid based de Bruijn graph algorithm for identifying complete coding genes from metagenomic and metatranscriptomic short reads. Nucleic Acids Research.
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TI2BioP allows mainly the calculation of topological indices (spectral moments) derived from inferred and artificial 2D structures of DNA, RNA and proteins being possible to carry out a structure-function correlation irrespective of sequence alignments. TI2BioP version 3.0 is a python platform with a graphical interface designed for Windows, Linux and Mac OS.
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PANDA-view
An easy-to-use tool for data visualization and statistical analysis
PANDA-view, an affiliated tool of PANDA, includes the methods for differentially expressed protein detection, missing value imputation and the parametric and non-parametric statistical tests. Meanwhile, the most commonly-used data visualization methods are also implemented in PANDA-view. -
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TSA_CRAFT
Automatic command line tool for TSA data analysis
DSF is a high-throughput platform of TSA assay to screen various conditions that affect protein stability. To facilitate TSA data analysis, we developed an automatic tool "TSA-CRAFT". TSA-CRAFT was developed by integrating PERL script and Gnuplot. PERL scripts manage the entire workflow and data processing procedures of TSA data analysis. On the other hand, Gnuplot takes over the curve fitting and result presentation works. All analysed results are coded in an html file that can be easily... -
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ENPG
A tool to extract potential neuropeptides from protein sequence data.
This tool is intended to extract potential neuropeptide regions from protein sequence data. The currently available version is dedicated to extract peptides that shows the structural hallmarks of cnidarian neuropeptides (C-terminal amidation, proline at N-terminus and pyro-Glutamate). The output FASTA file can be used as a target data set for peptide-spectrum matching to effectively narrow search space for highly sensitive peptide identifications. -
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altanalyze
Alternative splicing and functional prediction analysis tool
AltAnalyze is a freely available, open-source and cross-platform program that allows you to take RNASeq or relatively raw microarray data (CEL files or normalized), identify predicted alternative splicing or alternative promoter changes and view how these changes may affect protein sequence, domain composition, and microRNA targeting. AltAnalyze is compatible with any RNASeq data (exons and/or junctions), several Affymetrix splicing sensitive array types (Gene 1.0, Exon 1.0, junction) as well... -
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SAMFF
A Refined Empirical Force Field to Model Protein-SAM Interactions
Understanding protein interaction with material surfaces is important for the development of nanotechnological devices. The structures and dynamics of proteins can be studied via molecular dynamics (MD) if the protein-surface interactions can be accurately modeled. Based on AMBER14 and GAFF, we systematically tuned the Lennard-Jones parameters of selected amino acid sidechains and the functional group of SAM with repeated metadynamics and umbrella sampling simulations. The final parameter set... -
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CompleXChange
differential analysis of combinatorial protein complexes
The increasing wealth of transcriptomic data and current computational tools enable to infer how protein interactomes and complexomes may be assembled in specific samples. With CompleXChange this information can be exploited to conduct differential analyses of the dynamic protein complexome in a quantitative manner. The corresponding publication can be found on https://doi.org/10.1186/s12859-019-2852-z. -
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esPOS
A predictor to identify essential protein from PPI network
Predicting essential proteins from protein-protein interactions using order statistics -
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comer
Protein remote homology search tool
COMER is a protein sequence alignment tool designed for protein remote homology detection. It accepts a multiple sequence alignment as input and converts it into the profile to search a profile database for statistically significant similarities. COMER is licensed under the GNU GP License, version 3. Please find its archive file, download and extract it with the command "tar -zxf <archive-name>", and refer to the README file for instructions on how to use the software. Funding: This work... -
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ForceGen
Derives force constants from Gaussian QM for Gromacs MD
... the second order tensor of the Hessian from molecular fragments. The output has been made compatible with the Gromacs topology format. Examples of use include the derivation of bond force constants and equilibrium values for: -bonded metals in protein active sites -modified amino acids -small molecules/drug molecules A zip of examples files can be found by following the "Browse All Files" link. Written by Dr Anthony Nash (Oxford) Supported by Dr Thomas Collier, Prof Helen Birch & -
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AUTOMINv1.0
Automation for Minimization of Protein Data Bank Files, version 1.0
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Protein Microarray Analyser
Protein microarray data processing and normalization
The Protein Microarray Analyser software presented here includes the following tools: (1) neighbourhood background correction, (2) net intensity correction, (3) user-defined noise threshold, (4) user-defined CV threshold amongst replicates and (5) assay controls, (6) composite ‘pin-to-pin’ normalization amongst sub-arrays, and (7) ‘array-to-array’ normalization amongst whole arrays. -
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DACO-algorithm
A novel transcription factor complex prediction algorithm.
Eukaryotic gene expression is controlled through molecular logic circuits that combine regulatory signals of many different factors. Complexation of transcription factors and other regulatory proteins is a prevailing and highly conserved mechanism of signal integration within critical regulatory pathways and enable to infer controlled genes as well as the exerted regulatory mechanism. We developed DACO (domain-aware cohesiveness optimization), a novel algorithm that combines protein-protein... -
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hppRNA
A Snakemake-based handy parameter-free pipeline for RNA-Seq analysis
hppRNA package is dedicated to the RNA-Seq analysis for a large number of samples simultaneously from the very beginning to the very end, which is formulated in Snakemake pipeline management system. It starts from fastq files and will produce gene/isoform expression matrix, differentially-expressed-genes, sample clusters as well as detection of SNP and fusion genes by combination of the state-of-the-art software. The first version handles protein-coding genes, lncRNAs and circRNAs and includes... -
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POWAINDv1.0
Protein Water Interactions Determination, version 1.0
Crystallographic shell-waters that originate from diffraction data are an essential component, but not bulk water, of protein structure and stability. It interacts with various polar and non-polar components of protein. Polar backbone is constituted by O-type and N-type atoms of all residues. Polar side-chains are O, N, S containing groups of amino acid residues. Notably, ordered shell-waters form bridge interactions. Disordered shell-water may occupy central hydrophobic-cavity of protein... -
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ProDistiller
A software to perform quality control at protein level
ProDistiller is a quality-control tool based on the results of PepDistiller. ProDistiller focuses on QC at protein level and protein inference. Using PepDistiller and ProDistiller, you can obtain the QC results at both PSM and protein levels easily. -
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PTM-X
a solfware for predicting posttranslational modification cross-talk
The PTM-X (PTM cross-talk) project is a freely available bioinformatics software platform that allows to calculate the features of PTM pairs and the posterior probabilities of being cross-talk pairs. The prediction model is a naive Bayse classifier that integrats five features: protein sequence distance, tertiary structural distance, co-location in a disordered region, residue co-evolution, and modification co-evolution. An online tool is also available at http://bioinfo.bjmu.edu.cn/ptm-x/. -
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MS Data Miner
MS Data Miner - A web-based proteomics software
... validation-system and automatically screenshot generation tool for Mascot-assigned spectra. In addition, a GO term analysis function and a tool for generating comparative data-reports are included. The software is described in the following paper: Dyrlund TF, Poulsen ET, Scavenius C, Sanggaard KW, Enghild JJ. MS Data Miner: A web-based software tool to analyze, compare and share mass spectrometry protein identifications. PROTEOMICS 2012 http://www.ncbi.nlm.nih.gov/pubmed/22833312