...Sails is compatible with any front-end as well as any database thanks to its powerful ORM Waterline. Sails actions are compatible with Connect middleware, allowing you in most cases to simply paste code into Sails from an existing Express project and have everything work. You'll also be able to use WebSockets to talk to your API, and vice versa.
...As well as Angular (formerly Angular.js), which is a front-endweb app framework that runs your JavaScript code in the user's browser, allowing your application UI to be dynamic.
The emerge toolkit is a state-preserved web development framework. Build your whole application in one easy place. Uses O/R Mapping on the back-end, and Comet-style sockets on the front. http://emergetk.com