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...Yet, accurate quantification on species level is desirable in applications such as metagenomic diagnostics or community comparison. GASiC is a method to correct read alignment results for the ambiguities imposed by similarities of genomes. It has superior performance over existing methods.
You can find the accompanying paper here:
http://nar.oxfordjournals.org/content/41/1/e10.short
Thanks to the great work of the SeqAn team, you can now use GASiC as a Knime workflow:
https://github.com/seqan/knime_seqan_workflows/tree/master/metagenomics_gasic_workflow