Freevo is an open source HTPC media centre integrating PVR / DVR funtionality along with music, video, gaming, home automation and more. It is written in python and uses existing popular software such as mplayer, xine and vlc.
Snappy is a fast, easy to use, cross platform screenshot/screencast application currently being written in Python. It will integrate with many services, allowing the user to quickly upload to YouTube/ImageShack/FTP/etc.