Kivy is an open source, cross-platform UI framework that lets you develop applications that make use of innovative, multi-touch user interfaces. Written in Python with a graphics engine built over OpenGL ES 2, Kivy supports various input devices and protocols, and gives you access to over 20 widgets that are all highly extensible and have built-in multi-touch support. You can run the same codebase on Mac, Windows, Linux, Android and iOS.
Kivy is 100% free and open source with a professionally developed and used toolkit, as well as a stable framework and well-documented API, so you can be confident in using it in a commercial product.
Framework for making Windows applications that are one .exe file in AutoHotKey_L,C++,C#, VB.NET,Java,Groovy,Common Lisp,Nemerle,Ruby,Python,PHP,Lua,Tcl,Perl,Jint,S#,WSH VBScript,HTML/JavaScript/CSS,COM, PowerShell without compiling . For .NET 4.
The Mandragora World Engine is a C++/Python engine which allows the easy creation of programs, including applications, simulations, and games. Able to load and run specific program modules. Will handle objects, graphics, sound, physics, GUI, and even AI.