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EveryGui provides two applications: Chameleon, which is a dynamic GUI for virtually any tool or OS command, and Designer which is a visual environment for editing config files that determine Chameleon's different behaviours for each tool/command.
Sakura is a Knowledge Navigator and User Interface for UNIX, which implements HyperMedia and its own windowing and packing system, both in the main program and in an extensive API for Tcl and other languages.
SpinnyThing is a python module for displaying the progress of a task within an application. It supports a classic spinner w/ percentage-done and is easily extensible to include ascii animations to display progress.
Utilities for event handling in Tkinter. It has currently a function to process events without having to wait for Tkinter to process the event queue, that is: a painless event_generate()
PyUI2 is a cross platform user interface library written in Python. It is targeted primarily for game development, but can be used as a user interface for other applications.This version has been forked from the original Pyui library.
yuik is an abstract widget library for creating GUIs. The actual frontend can be chosen at runtime which allows the program to run under Tk, as a shell program, and even as a web-application. More frontends like an irc-bot, wxWidgets, or XUL are planned.
...The tool should provide a simple way to log the user's mouse movements in the background for (later) analysis. Currently only for Mac OS X (ObjC & Cocoa), planned to make platform independent with Python. It consists out of two
wxBrowser is an application browser based on the wxWidgets GUI framework. It's similar to a regular old web browser only, instead of reading HTML and displaying content it reads XML and executes presentation logic (wxPython) in a client side application.
Ophidian is a Python module created to easily develop wxPython user interfaces. Ophidian provides wrapper classes to transparently load XRC resources and access the user controls inside them, with a minimum of coding effort.
ACDK - Artefaktur Component Development Kit - is a platform independent C++-framework similar to Java or C#/.NET for generating distributed and scriptable components and applications.
Educational game framework supporting board games, strategy games, and other grid-based game boards. Currently uses Python/wxPython as the application language/library. C++ libs included to help create AI for the various games.
InterPython (stands Python InterOperability) is a .NET library that allows a python interpreter to be "embedded" in your .NET programs, and gives you (almost) transparent access to python libraries and services in .NET programs. Great for GUIs, etc.
GILA: Graphical Interface Logistics Application. GILA is meant to provide a configurable, object oriented user interface, that is capable of interacting with existing applications via user configuration.
FXPy is a Python extension module that provides an interface to the cross-platform FOX GUI library. It is no longer under development, but the last release is compatible with FOX 1.0 and Python 2.2.
Full blender integrated documentation and multi-language translation (help) > Python script for Blender, a free open source 3D content creation suite, available for all major operating systems under the GNU General Public License.
Baum is a Qt based GUI application framework with a built in python interpreter. Baum allows rapid creation of GUI's with simple python scripts. Programmers can re-use available python and widget library.
The PyQt4D (Python Qt for Designer) is an Open Source Project making Qt Designer full-featured RAD (Rapid Application Development) tool to develop data-aware two- or multi-tier applications using Python language and Qt library.
Threadmill is a compact and powerful set of tools that integrates parsing and intuitive multithreadability with command-line programs written in the Python programming language.
Guide is a Python library for UI layout and data-binding which is cross-platform and supports multiple UI libraries. It allows users to quickly iterate on design and functionality of UIs using an xml markup-language.