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Vinux is an Ubuntu derived distribution for blind & visually impaired.
Vinux supports software text to speech and Braille support from boot-up to shutdown.
Users can use installation medium to install independently with no sighted assistance required.
Vinux supports commandline environment speech, Desktop environment speech and magnification features.
Vinux comes with an accessible suite of software and has an excellent mailing list support group.
C# app (using Windows RSS Platform, Microsoft Feeds 2.0) with SysTray icon and pop-up balloons to indicate new feed items. Provides hook for Text-To-Speech, by starting a (configurable) process (like Festival) with each new item as command-line argument.