Python.NET
Package that gives Python programmers integration with .NET Common CLR
... not implement Python as a first-class CLR language - it does not produce managed code (IL) from Python code. Rather, it is an integration of the CPython engine with the .NET or Mono runtime. This approach allows you to use CLR services and continue to use existing Python code and C-API extensions while maintaining native execution speeds for Python code. If you are interested in a pure managed-code implementation of the Python language, you should check out the IronPython project.