...In addition to this, parallel programming approaches increase the computation performance. Therefore, this study focuses to discuss and solve the route planning problem for multi-UAV systems by using optimization techniques based on an evolutionary algorithm: simulated annealing. The travel cost and execution time are downsized in this work by optimization on algorithm and code. We implemented CPU based parallel solution to compare results with the GPU-accelerated one. The efficiency and the effectiveness of our parallelized and optimized solution